Development and validation of an UPLC-MS/MS assay for the simultaneous quantification of seven commonly used antibiotics in human plasma and its application in therapeutic drug monitoring.
Xin Meng MekkingKirsten Velthoven-GraaflandMarga J A TeulenRoger J M BrüggemannLindsey H M Te BrakeNynke G L JagerPublished in: The Journal of antimicrobial chemotherapy (2024)
The method provided reliable, precise and accurate measurement of seven commonly prescribed antibiotics, including the unbound concentration of flucloxacillin. This method is now routinely applied in research and clinical practice.