Glycoside constituents from Cayratia geniculata .
Dang Viet CuongTran Thi Hong HanhPham Thi Mai HuongNguyen Thi HuongTran Hong QuangNguyen Xuan CuongPublished in: Journal of Asian natural products research (2024)
Using various chromatographic separations, six glycoside derivatives ( 1-6 ), including one new ent -labdane glucoside named cayratioside ( 1 ), were isolated from the methanol extract of Cayratia geniculata stems and leaves. Their structures were elucidated by detailed analysis of the 1D, 2D NMR, and HRESIQTOF mass spectra. The inhibitory effect of 1-6 on LPS-induced NO production in RAW264.7 cells was also evaluated. Among isolated compounds, 1 exhibited moderate activity with an IC 50 value of 59.65 ± 1.85 µM.
Keyphrases
- lps induced
- inflammatory response
- induced apoptosis
- high resolution
- cell cycle arrest
- oxidative stress
- magnetic resonance
- essential oil
- endoplasmic reticulum stress
- simultaneous determination
- density functional theory
- signaling pathway
- cell death
- carbon dioxide
- solid state
- mass spectrometry
- anti inflammatory
- pi k akt
- liquid chromatography