G-quadruplexes are transcription factor binding hubs in human chromatin.

Jochen SpiegelSergio Martínez CuestaSantosh AdhikariRobert Hänsel-HertschDavid TannahillSamantha Kendrick

Published in: Genome biology (2021)

Our results reveal a novel non-canonical mechanism for TF binding whereby G4s operate as common binding hubs for many different TFs to promote increased transcription.

Keyphrases

transcription factor
dna binding
endothelial cells
genome wide
binding protein
gene expression
dna damage
single cell