An integrated transcriptomics and network pharmacology approach to explore the mechanism of Wang-Bi tablet against SAPHO syndrome.

Ting WangXun GongCongmin XiaWeijia KongShaohui GengHaixu JiangEnfan XiaoHesong WangYingcai YuXiujuan HouKai Yuan

Published in: International journal of rheumatic diseases (2024)

This study illustrated that the possible mechanisms of WBT against SAPHO syndrome may be related to NIK/NF-kappaB-, MyD88-dependent toll-like receptor-, and MAPK pathway, and further experiments are needed to prove these predictions.

Keyphrases

toll like receptor
nuclear factor
signaling pathway
inflammatory response
immune response
oxidative stress
pi k akt
case report
lps induced
single cell
cell proliferation
network analysis