Reduced Endocannabinoid Tone in Saliva of Chronic Orofacial Pain Patients.

Yaron HavivOlga GeorgievTal Gaver-BrachaSharleen HamadAlina NemirovskiRivka HadarYair SharavDoron J AframianYariv BrotmanJoseph Tam

Published in: Molecules (Basel, Switzerland) (2022)

lower levels of eCBs were found in the saliva of chronic OFP patients compared to controls, specifically those with neurovascular/migraine, and neuropathic pain. The detection of changes in salivary endocannabinoids levels related to OFP adds a new dimension to our understanding of OFP mechanisms, and may have diagnostic as well as therapeutic implications for pain.

Keyphrases

neuropathic pain
end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
chronic pain
spinal cord
spinal cord injury
peritoneal dialysis
prognostic factors
pain management
patient reported outcomes
quantum dots
patient reported
sensitive detection
label free