Secretory autophagy promotes Rab37-mediated exocytosis of tissue inhibitor of metalloproteinase 1.

Shan-Ying WuJia-Wen ChenHsi-Yu LiuYi-Ching WangYeh-Shiu ChuChi-Ying HuangKai-Ying LanHsiao-Sheng LiuSheng-Hui Lan

Published in: Journal of biomedical science (2022)

We are the first to report that autophagy plays a promoting role in TIMP1 secretion and metastasis in a Rab37-dependent manner in lung cancer cells and the lung-to-lung mouse model.

Keyphrases

mouse model
cell death
endoplasmic reticulum stress
signaling pathway
oxidative stress