Actovegin® reduces PMA-induced inflammation on human cells.

Franz-Xaver ReichlChristof HöggFangfang LiuMarkus SchwarzDaniel TeupserReinhard HickelWilhelm BlochHelmut SchweiklPeter ThomasBurkhard Summer

Published in: European journal of applied physiology (2020)

Actovegin® can reduce the PMA-induced IL-1beta release and the ROS production from PBMCs. These findings may help to explain the clinically known positive effects of Actovegin® on athletic injuries with inflammatory responses (e.g., muscle injuries, tendinopathies).

Keyphrases

high glucose
diabetic rats
oxidative stress
skeletal muscle
drug induced
cell death
endothelial cells
reactive oxygen species