Rbbp4 loss disrupts neural progenitor cell cycle regulation independent of Rb and leads to Tp53 acetylation and apoptosis.
Laura E Schultz-RogersMichelle L ThayerSekhar KambakamWesley A WiersonJordan A HelmerMark D WishmanKristen A WallJessica L GreigJaimie L ForsmanKavya PuchhalapalliSiddharth NairTrevor J WeissJon M LuikenPatrick R BlackburnStephen C EkkerMarcel KoolMaura McGrailPublished in: Developmental dynamics : an official publication of the American Association of Anatomists (2022)
Rbbp4 is necessary for neural progenitor cell cycle progression and initiation of G0 independent of Rb. Tp53-dependent apoptosis in the absence of Rbpb4 correlates with Tp53 acetylation. Together these results suggest that Rbbp4 is required for cell cycle exit and contributes to neural progenitor survival through the regulation of Tp53 acetylation.