Development, Validation, and Clinical Application of an Ultra-High-Performance Liquid Chromatography Coupled With Tandem Mass Spectrometry Method for the Determination of 10 Antituberculosis Drugs in Human Serum.
Xudong FanSuhang GuoRuoying ZhangQingshan CaiYazhen LangJinpeng HuangYuanyuan ChenYing ZhangYingying XuMeng ChenGaoyi YangXinjun CaiPublished in: Therapeutic drug monitoring (2024)
A simple and reliable analytical method was developed and validated for the simultaneous determination of 10 anti-TB drugs in human serum using UHPLC-MS/MS. Quantitation of anti-TB drugs in clinical samples confirmed that the assay is suitable for therapeutic drug monitoring in regular clinical practice.
Keyphrases
- tandem mass spectrometry
- ultra high performance liquid chromatography
- simultaneous determination
- liquid chromatography
- solid phase extraction
- ms ms
- high performance liquid chromatography
- liquid chromatography tandem mass spectrometry
- gas chromatography
- high resolution mass spectrometry
- mass spectrometry
- high resolution
- clinical practice
- molecularly imprinted
- mycobacterium tuberculosis
- drug induced
- high throughput