Fulminant necrotizing fasciitis to the hand in a patient on high-dose steroids: A case report of successful limb salvage.
Miguel A JohnsonJuan BernerGeorge ChristopoulosPreci L HamiltonRobert PearlPublished in: Journal of surgical case reports (2020)
Glucocorticoids are commonly used in the management of patients with brain Tumour for reducing peritumoral and vasogenic edema. However, they may lead to development of limb and life-threatening conditions such as necrotizing fasciitis (NF). NF is a rare but potentially lethal condition. Early detection and aggressive treatment may lead to decreased mortality and limb salvage. The diagnosis is predominately clinical but may be supported by laboratory and radiological investigations. Chronic steroid use not only predisposes to the development of NF but also may mask early features delaying presentation and diagnosis. Clinicians should have a high index of suspicion especially in patients on chronic steroid therapy as this may aid in early detection and treatment. We present a case report of a successful limb salvage that exemplifies these points.
Keyphrases
- signaling pathway
- high dose
- lps induced
- oxidative stress
- nuclear factor
- pi k akt
- ejection fraction
- case report
- newly diagnosed
- palliative care
- cardiovascular disease
- risk factors
- type diabetes
- inflammatory response
- immune response
- resting state
- stem cell transplantation
- combination therapy
- coronary artery disease
- cerebral ischemia
- functional connectivity
- brain injury