A nontoxic fungal natural product modulates fin regeneration in zebrafish larvae upstream of FGF-WNT developmental signaling.

Paul CavanahJunji ItouYudi RusmanNaoyuki TaharaJessica M WilliamsChristine E SalomonYasuhiko Kawakami

Published in: Developmental dynamics : an official publication of the American Association of Anatomists (2020)

Colomitide C, a natural product, modulated larvae fin regeneration likely acting upstream of FGF and WNT signaling. Colomitide C may serve as a template for developing new chemical probes to study regeneration and other biological processes.

Keyphrases

stem cells
aedes aegypti
small molecule
cell proliferation
drosophila melanogaster
single molecule
fluorescence imaging
mass spectrometry
high resolution
molecularly imprinted