Extensive profiling of histidine-containing dipeptides reveals species- and tissue-specific distribution and metabolism in mice, rats, and humans.
Thibaux Van der StedeJan SpaasSarah de JagerJana de BrandtCamilla Collin HansenJan StautemasBjarne VercammenSiegrid De BaereSiska CroubelsCharles-Henri Van AsscheBerta Cillero PastorMichiel VandenboschRuud Van ThienenKenneth VerbovenDominique HansenThierry BoveBruno LapauwCharles Van PraetKarel DecaesteckerBart VanaudenaerdeBert O EijndeLasse GliemannYlva HellstenWim DeravePublished in: Acta physiologica (Oxford, England) (2023)
Collectively, we provide a novel basis to unravel tissue-specific, paracrine, and endocrine roles of HCDs in human health and disease.