A Systematic Evaluation of Cost-Saving Dosing Regimens for Therapeutic Antibodies and Antibody-Drug Conjugates for the Treatment of Lung Cancer.
Rob Ter HeineMichel M van den HeuvelBerber PietMaarten J DeenenAnthonie J van der WekkenLizza E L HendriksSander CroesRobin M J M van GeelFrank G A JansmanRogier C BoshuizenEric J F FranssenArthur A J SmitDaphne W DumoulinThijs H Oude MunninkEgbert F SmitHieronymus J DerijksCor H van der LeestJeroen J M A HendrikxDirk J A R MoesNikki de RouwPublished in: Targeted oncology (2023)
Dosing regimens based on weight bands and the use of complete vials to reduce drug wastage result in less expenses while maintaining equivalent exposure. The level of evidence of our proposal is the same as accepted by regulatory authorities for the approval of alternative dosing regimens of other monoclonal antibodies in oncology. The proposed alternative dosing regimens can, therefore, be directly implemented in clinical practice.