Complement activation predicts adverse pregnancy outcome in patients with systemic lupus erythematosus and/or antiphospholipid antibodies.
Mimi Y KimMarta M GuerraElianna KaplowitzCarl A LaskinMichelle PetriD Ware BranchMichael D LockshinLisa R SammaritanoJoan T MerrillT Flint PorterAllen SawitzkeAnne M LynchJill P BuyonJane E SalmonPublished in: Annals of the rheumatic diseases (2018)
In pregnant patients with SLE and/or aPL, increased Bb and sC5b-9 detectable early in pregnancy are strongly predictive of APOs and support activation of complement, particularly the alternative pathway, as a contributor to APOs.