Stellane at the Forefront: Derivatization and Reactivity Studies of a Promising Saturated Bioisostere of ortho -Substituted Benzenes.
Oleh K SmyrnovKostiantyn P MelnykovOlexandr Ye PashenkoDmitriy M VolochnyukSergey V RyabukhinPublished in: Organic letters (2024)
This work highlights stellane's cage stability and derivatization opportunities. A diverse range of building blocks were synthesized using modern synthesis protocols to demonstrate stellane's reactivity and chemical tolerance across different reaction systems, proving its promise as a bioisosteric scaffold. It can be utilized in scaffold-based molecular design and is superior in terms of topological precision compared to existing ortho isosteres, as well as monosubstituted benzene mimetics, holding the potential to become a robust platform for future medicinal chemistry studies.
Keyphrases
- ms ms
- liquid chromatography tandem mass spectrometry
- gas chromatography mass spectrometry
- high performance liquid chromatography
- case control
- simultaneous determination
- liquid chromatography
- tissue engineering
- gas chromatography
- tandem mass spectrometry
- molecular docking
- high throughput
- current status
- big data
- risk assessment
- machine learning
- drug discovery
- single molecule