Depletion of Mannose Receptor-Positive Tumor-associated Macrophages via a Peptide-targeted Star-shaped Polyglutamate Inhibits Breast Cancer Progression in Mice.
Anni LeplandAlessio MalfantiUku HaljasorgEliana K AsciuttoMónica PickholzMauro BringasSnežana ĐorđevićLiis SalumäePärt PetersonTambet TeesaluMaría Jesus VicentPablo ScodellerPublished in: Cancer research communications (2022)
A peptide-targeted nanoformulation of DOX exclusively eliminates mannose receptor+ TAMs in breast cancer models, generating response without off-target effects (a drawback of many TAM-depleting agents under clinical study).