CRACD, a gatekeeper restricting proliferation, heterogeneity, and immune evasion of small cell lung cancer.
Shengzhe ZhangKee-Beom KimYuanjian HuangDong-Wook KimBongjun KimKyung-Pil KoGengyi ZouJie ZhangSohee JunNicole A KirkYe Eun HwangYoung Ho BanJoseph M ChanCharles M RudinKwon-Sik ParkJae-Il ParkPublished in: bioRxiv : the preprint server for biology (2023)
T cells via the epigenetic suppression of the MHC-I pathway. Furthermore, single-cell transcriptomics stratified SCLC patients by concurrent features: CRACD inactivation and tumor antigen presentation impairment. This study identifies CRACD as a tumor suppressor that restricts the proliferation and immune recognition of SCLC cells, providing novel insight into how SCLC evades immune surveillance.
Keyphrases
- single cell
- small cell lung cancer
- end stage renal disease
- rna seq
- signaling pathway
- induced apoptosis
- newly diagnosed
- ejection fraction
- chronic kidney disease
- public health
- gene expression
- high throughput
- peritoneal dialysis
- cell cycle arrest
- prognostic factors
- genome wide
- cell proliferation
- squamous cell carcinoma
- endoplasmic reticulum stress
- oxidative stress
- radiation therapy
- brain metastases
- case report