Direct Binding to NLRP3 Pyrin Domain as a Novel Strategy to Prevent NLRP3-Driven Inflammation and Gouty Arthritis.
Gabsik YangHye E LeeSu-Jin MoonKyung M KoJung H KohJin K SeokJun-Ki MinTae-Hwe HeoHan C KangYong-Yeon ChoHye S LeeKatherine A FitzgeraldJoo Young LeePublished in: Arthritis & rheumatology (Hoboken, N.J.) (2020)
Our results present β-carotene as a selective and direct inhibitor of NLRP3, and the binding of β-carotene to NLRP3 PYD as a novel pharmacologic strategy to combat NLRP3 inflammasome-driven diseases, including gouty arthritis.