Antibody-mediated disruption of the SARS-CoV-2 spike glycoprotein.
Antoni G WrobelDonald J BentonSaira HussainRuth HarveyStephen R MartinChloë RoustanPeter B RosenthalJohn J SkehelSteven J GamblinPublished in: Nature communications (2020)
The CR3022 antibody, selected from a group of SARS-CoV monoclonal antibodies for its ability to cross-react with SARS-CoV-2, has been examined for its ability to bind to the ectodomain of the SARS-CoV-2 spike glycoprotein. Using cryo-electron microscopy we show that antibody binding requires rearrangements in the S1 domain that result in dissociation of the spike.