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A causal proportional hazards estimator under homogeneous or heterogeneous selection in an IV setting.

Ditte Nørbo SørensenTorben MartinussenEric Tchetgen Tchetgen
Published in: Lifetime data analysis (2019)
In this paper we present a framework to do estimation in a structural Cox model when there may be unobserved confounding. The model is phrased in terms of a selection bias function and a baseline model that describes how covariates affect the survival time in a scenario without exposure. In this way model congeniality is ensured. The method uses an instrumental variable. Interestingly, the formulated model turns out to have similarities to the so-called Cox-Aalen survival model for the observed data. We exploit this to enhance estimation of the unknown parameters. This also allows us to derive large sample properties of the proposed estimator.
Keyphrases
  • machine learning
  • deep learning
  • free survival