Direct assessment of individual skin barrier components by electrical impedance spectroscopy.
Roman MannweilerSophia BergmannSabine Vidal-Y-SyJohanna M BrandnerDorothee GünzelPublished in: Allergy (2021)
In conclusion, the present technique allows to separately measure the barrier properties of SC and VE and further evaluate the Cldn1 and 4 knockdown impact on the skin barrier. As the measurement with agarose-embedded electrolyte allowed non-invasive identification of the Cldn1 knockdown, this opens the way to detailed in vivo skin barrier assessment.