Altered thyroid feedback loop in Klinefelter syndrome: a cohort study from infancy through the transition into adulthood.

Francesco Carlomagno Marianna MinnettiFrancesco AngeliniRiccardo Pofi Emilia Sbardella Matteo Spaziani Alessia AureliAntonella AnzuiniRoberto Paparella Luigi TaraniTommaso PorcelliMaria Angela De StefanoCarlotta Pozza Daniele Gianfrilli Andrea M Isidori

Published in: The Journal of clinical endocrinology and metabolism (2023)

From infancy through adulthood, KS is characterized by increased morpho-functional abnormalities of the thyroid gland, combined with a central feedback dysregulation sustained by the effect of hypogonadism on D2 deiodinase.

Keyphrases

depressive symptoms
weight gain
early life
case report
transcription factor
replacement therapy
physical activity