Genetic and Non-Genetic Factors Impact on INR Normalization in Preprocedural Warfarin Management.

Islam El JilanyMohamed ElarrefNabil Adbelhamid Shallik Abdel-Nasser ElzoukiLoulia BaderAhmed El-BardissyOsama AbdelsamadDaoud Al-BadriyehLarisa H CavallariHazem F Elewa

Published in: Pharmacogenomics and personalized medicine (2021)

Despite the confirmed effect of genetic factors on warfarin maintenance dose, the study was not able to find a significant effect of any genetic factor on the rate of INR normalization possibly due to the small sample size. Index INR and interacting medications showed to be significant predictors of INR decline rate.

Keyphrases

genome wide
copy number
atrial fibrillation
venous thromboembolism
dna methylation
gene expression
oral anticoagulants