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Par14 interacts with the androgen receptor, augmenting both its transcriptional activity and prostate cancer proliferation.

Miki NaitoKenichiro IkedaShunya AoyamaMayu KanamotoYasuyuki AkasakaYuri KidoMikako NakanishiMachi KannaTakeshi YamamotoyaAkio MatsubaraNobuyuki HinataTomoichiro AsanoYusuke Nakatsu
Published in: Cancer medicine (2022)
Thus, Par14 plays a critical role in PCa progression, and its enhancing effects on AR signaling are likely to be involved in the underlying molecular mechanisms. These findings suggest Par14 to be a promising therapeutic target for PCa.
Keyphrases
  • prostate cancer
  • radical prostatectomy
  • signaling pathway
  • gene expression
  • transcription factor