Exosomes Derived from CXCR4-Overexpressing BMSC Promoted Activation of Microvascular Endothelial Cells in Cerebral Ischemia/Reperfusion Injury.

Xutong Li Ye Zhang Yong Wang Dan Zhao Chengcheng Sun Shaoting Zhou Dongsheng Xu Jing Zhao

Published in: Neural plasticity (2020)

In ischemia/reperfusion injury, ExoCXCR4 promoted the proliferation and tube formation of microvascular endothelial cells and play an antiapoptotic role via the Wnt-3a/β-catenin pathway.

Keyphrases

endothelial cells
ischemia reperfusion injury
stem cells
high glucose
mesenchymal stem cells
oxidative stress
signaling pathway
vascular endothelial growth factor
subarachnoid hemorrhage
cell proliferation
cell migration
cerebral ischemia
brain injury