A variety of workplace exposures (organic or inorganic dusts as well as gases, fumes, or vapors) can cause diffuse interstitial lung disease. The latency period until onset of the disease can exceed 30 years. The disease course varies greatly and depends on the quantity of the inhaled substance and its fibrogenic effect. Pulmonary high-resolution computed tomography (HRCT) patterns do not differ significantly from those of interstitial lung diseases (ILD) of other etiologies. Therefore, without knowledge of the occupational history, work-related ILDs are often classified as idiopathic. In addition, there is increasing evidence in the recent literature that high exposure to silica dust can trigger autoimmune diseases (also involving the lungs). For this reason, a qualified occupational history is now an indispensable part of the interdisciplinary diagnosis of ILDs.
Keyphrases
- interstitial lung disease
- systemic sclerosis
- computed tomography
- high resolution
- rheumatoid arthritis
- idiopathic pulmonary fibrosis
- systematic review
- healthcare
- cystic fibrosis
- air pollution
- positron emission tomography
- mass spectrometry
- water soluble
- risk assessment
- low grade
- heavy metals
- magnetic resonance
- tandem mass spectrometry
- health promotion
- climate change
- drinking water