Structural network changes in cerebral small vessel disease.
Anil Man TuladharJonathan TayEsther van LeijsenAndrew J LawrenceIngeborg Wilhelmina Maria van UdenMayra BergkampEllen van der HolstRoy P C KesselsDavid NorrisHugh S MarkusFrank-Erik De LeeuwPublished in: Journal of neurology, neurosurgery, and psychiatry (2019)
Disruption of the network efficiency, a metric assessing the efficiency of network information transfer, plays an important role in explaining cognitive decline in SVD, which was however not independent of imaging markers of SVD. Furthermore, baseline network efficiency predicts risk of mortality in SVD that may reflect the global health status of the brain in SVD. This emphasises the importance of structural network analysis in the context of SVD research and the use of network measures as surrogate markers in research setting.