Identification of a novel DNA oxidative damage repair pathway, requiring the ubiquitination of the histone variant macroH2A1.1.

Khalid OuararhniFlore MiettonJamal S M SabirAbdulkhaleg IbrahimAnnie MollaRaed S AlbheyriAli T ZariAhmed BahieldinHervé MenoniChristian BronnerStefan DimitrovAli Hamiche

Published in: BMC biology (2024)

Our data identify a novel pathway for the repair of DNA oxidative lesions, requiring the ubiquitination of mH2A for the release of PARP-1 from chromatin and its activation.

Keyphrases

circulating tumor
dna damage
cell free
single molecule
gene expression
dna methylation
transcription factor
big data
nucleic acid