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Proof of Concept: Development of a Mitral Annuloplasty Ring With Crosshatch Net.

Benjamin D SeadlerDavid L JoyceJames ZeltenKevin SweeneyTaylor WisgerhofZoey SlettehaughY William YuanBrandon TefftPaul J Pearson
Published in: Innovations (Philadelphia, Pa.) (2024)
The study device effectively reduced mitral valve regurgitation and improved hemodynamics in our preclinical model with similar biophysical metrics to currently approved devices. Future in vivo trials are needed to evaluate the efficacy, biocompatibility, and freedom from the most likely adverse events, such as device thrombosis, embolic events, and hemolysis.
Keyphrases
  • mitral valve
  • left atrial
  • left ventricular
  • pulmonary embolism
  • current status
  • heart failure
  • aortic stenosis
  • drug administration
  • tissue engineering