Multiple deuteration of triphenylphosphine and live-cell Raman imaging of deuterium-incorporated Mito-Q.

Shogo MoriyamaMiyu MaeDaiki ShibataHiroyuki YamakoshiShinji Kajimoto Takakazu Nakabayashi Takayoshi IshimotoKaiki MogiHironao Sajiki Shuji Akai Yoshinari Sawama

Published in: Chemical communications (Cambridge, England) (2023)

All aromatic C-H bonds of triphenylphosphine (PPh 3 ) were efficiently replaced by C-D bonds using Ru/C and Ir/C co-catalysts in 2-PrOH and D 2 O, an inexpensive deuterium source. Furthermore, non-radioactive and safe deuterium-incorporated Mito-Q (drug candidate) was prepared from deuterated PPh 3 and used for the live-cell Raman imaging to evaluate the mitochondrial uptake.

Keyphrases

high resolution
oxidative stress
emergency department
amino acid
mass spectrometry
fluorescence imaging
photodynamic therapy