ATXN1 N-terminal region explains the binding differences of wild-type and expanded forms.

Sara RochaJorge VieiraNoé VázquezHugo López-FernándezFlorentino Fdez-RiverolaMiguel Reboiro-JatoAndré D SousaCristina P Vieira

Published in: BMC medical genomics (2019)

There are three regions at the AXH domain that are essential for ATXN1 PPI. The N-terminal region is responsible for the strength of the PPI with the ATXN1 variants. How the predicted motifs in this region affect PPI is discussed, in the context of ATXN1 post-transcriptional modifications.

Keyphrases

wild type
protein protein
gene expression
copy number
small molecule
oxidative stress
dna methylation
binding protein