The Burden of Breast Cancer Predisposition Variants Across The Age Spectrum Among 10 000 Patients.

Yanin Chavarri-GuerraCarolyn B HendricksSandra BrownCatherine MarcumMary HanderZdenka E SegotaChris HakeSharon SandThomas P SlavinArti HurriaEnrique Soto Pérez de CelisBita NehorayKenneth B BlanksteinKathleen R BlazerJeffrey N Weitzelnull null

Published in: Journal of the American Geriatrics Society (2019)

Clinically actionable BC susceptibility PVs, particularly in BRCA2 and CHEK2, were relatively prevalent among older women undergoing genetic testing. The significant burden of PVs for older women with BC provides a critical reminder to recognize the full spectrum of eligibility and provide genetic testing for older women, rather than exclusion based on chronological age alone. J Am Geriatr Soc 67:884-888, 2019.

Keyphrases

risk factors
copy number
physical activity
middle aged
gene expression
young adults
dna methylation