Quantification of HTLV-1 reverse transcriptase activity in ATL patients treated with zidovudine and interferon-α.
Beatrice MacchiEmanuela BalestrieriCaterina FrezzaSandro GrelliElena VallettaAmbroise MarçaisFrancesca Marino-MerloJocelyn TurpinCharles R M BanghamOlivier HermineAntonio MastinoAli BazarbachiPublished in: Blood advances (2017)
The therapeutic efficacy of the AZT and IFN combination in ATL presumably reflects the inhibition of RT-related functions.HTLV-1-RT activity from short-term cultured PBMCs may represent a predictive correlate of clinical response to AZT/IFN in ATL patients.