Overexpression of OASL upregulates TET1 to induce aberrant activation of CD4 + T cells in systemic sclerosis via IRF1 signaling.

Zhuotong ZengYaoyao WangYangfan XiaoJie ZhengRuizhen LiuXinglan HeJiangfan YuBingsi TangXiangning QiuRui TangYaqian ShiRong Xiao

Published in: Arthritis research & therapy (2022)

OASL participates in the regulation of abnormal hypomethylation of CD4+ T cells in SSc, which implies a pivotal role for IFN signaling in the pathogenesis of SSc. Regulating DNA methylation and IFN signaling may serve as therapeutic treatments in SSc.

Keyphrases

systemic sclerosis
dna methylation
dendritic cells
interstitial lung disease
immune response
gene expression
cell proliferation
genome wide