Correlation analysis between auto-immunological and mutational profiles in myelodysplastic syndromes.

Antonio CristianoRiccardo BelardiHajro HajrullajEmiliano FabianiGiulia FalconiElisa GalossiSergio BernardiniMaria Teresa VosoMarzia Nuccetelli

Published in: Inflammation research : official journal of the European Histamine Research Society ... [et al.] (2023)

Although ANA-positivity was found to be increased in MDS, the low ANA-antigenic-specificity suggests that autoantibodies didn't recognize autoimmune-pathognomonic antigens. The lack of relationship between genetic profile and ANA-positivity, suggests that MDS genetic variants may not be the direct cause of SIAD.

Keyphrases

systemic lupus erythematosus
multiple sclerosis
genome wide
dendritic cells
copy number
immune response
structural basis
data analysis