Frontotemporal neurofibrillary tangles and cerebrovascular lesions are associated with autism spectrum behaviors in late-life dementia.

Elizabeth K RhodusJustin BarberRichard J KryscioErin L AbnerAhmed A BahraniKristine E Shady LewisBrandi CareyPeter T NelsonLinda J Van EldikGregory A Jicha

Published in: Journal of neurology (2022)

This study links behaviors characteristic of autism to increased pathologic tau burden in the frontal and temporal lobes in persons with late-life dementia. Additional studies are needed to determine causal factors and treatment options for behaviors characteristic of autism behaviors in late-life dementias.

Keyphrases

autism spectrum disorder
intellectual disability
mild cognitive impairment
cognitive impairment
squamous cell carcinoma
working memory
functional connectivity
risk factors
amyotrophic lateral sclerosis