ROR2 regulates cellular plasticity in pancreatic neoplasia and adenocarcinoma.

Simone BenitzAlec SteepMalak NasserJonathan PreallUjjwal M MahajanHolly McQuitheyIan LovelessErick T DavisHui-Ju WenDaniel W LongThomas MetzlerSamuel ZwernikMichaela LouwDonald RempinskiDaniel Salas-EscabillasSydney BrenderLinghao SongLing HuangZhenyu ZhangNina G SteeleIvonne RegelFilip BednarHoward C Crawford

Published in: bioRxiv : the preprint server for biology (2024)

We discovered the receptor tyrosine kinase ROR2 as an important regulator of cellular identity in pancreatic precancerous lesions and pancreatic cancer. ROR2 drives an aggressive PDAC phenotype and confers resistance to Kras inhibitors, suggesting that targeting ROR2 will enhance sensitivity to this new generation of targeted therapies.

Keyphrases

tyrosine kinase
epidermal growth factor receptor
squamous cell carcinoma
high grade
cancer therapy
drug delivery