DNA methylation and behavioral dysfunction in males with 47,XXY and 49,XXXXY: a pilot study.

Richard S LeeSophia Q SongHenri M Garrison-DesanyJenny L CareyPatricia LasutschinkowAndrew ZabelJoseph BresslerAndrea GropmanCarole A Samango-Sprouse

Published in: Clinical epigenetics (2021)

Boys with 49,XXXXY displayed higher levels of CpG methylation at regulatory intronic regions in X-linked genes encoding the androgen receptor (AR) and monoamine oxidase A (MAOA), compared to that in boys with 47,XXY and neurotypical boys. Our pilot study results suggest a link between CpG methylation levels and behavior in boys with 49,XXXXY.

Keyphrases

dna methylation
genome wide
gene expression
copy number
oxidative stress