Modulation of factor VIII pharmacokinetics by genetic components in factor VIII receptors.

Barbara Lunghi Massimo Morfini Nicola Martinelli Alessio Branchini Silvia Linari Giancarlo Castaman Francesco Bernardi

Published in: Haemophilia : the official journal of the World Federation of Hemophilia (2022)

With the limitation of the small number of HA patients, these observations highlight multiple genetic components acting in distinct phases of FVIII PK and contributing to explain FVIII PK variability. This analysis provides candidates for genotype-based, individual tailoring of FVIII substitutive treatment.

Keyphrases

end stage renal disease
ejection fraction
newly diagnosed
genome wide
chronic kidney disease
peritoneal dialysis
gene expression
patient reported outcomes
patient reported
replacement therapy