Ameliorating role of microRNA-378 carried by umbilical cord mesenchymal stem cells-released extracellular vesicles in mesangial proliferative glomerulonephritis.

Wenbiao ChenFeng ZhangXianliang HouHuixuan XuDonge Tang

Published in: Cell communication and signaling : CCS (2022)

UcMSC-Evs ameliorate pathological process in MsPGN through the delivery of miR-378, which suppresses PSMD14-mediated TGFBR1 stability and inactivates the TGF-β1/Smad2/3 signaling pathway to reduce tissue hyperplasia and rMC proliferation. Video abstract.

Keyphrases

umbilical cord
signaling pathway
mesenchymal stem cells
transforming growth factor
epithelial mesenchymal transition
pi k akt
cell proliferation
long non coding rna
induced apoptosis
long noncoding rna
bone marrow
diabetic nephropathy
high glucose
cell therapy
stem cells
endoplasmic reticulum stress