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Pharmacokinetics of Brexpiprazole, Quetiapine, Risperidone, and Its Active Metabolite Paliperidone in a Postpartum Woman and Her Baby.

Toru KonishiYumi KitahiroNaoko FujiwaraKazuhiro YamamotoMari HashimotoTakahiro ItoKotaro ItoharaKazumichi FujiokaHitomi ImafukuIkuo OtsukaTomohiro OmuraIkuko Yano
Published in: Therapeutic drug monitoring (2024)
Pregnancy status notably alters the pharmacokinetic properties of antipsychotics. Therefore, close and careful monitoring of clinical symptoms should be considered during pregnancy and after delivery. Although brexpiprazole is transferred to neonates through the placenta, breastfeeding is still possible because the relative infant dose value of this drug was much less than 10%.
Keyphrases
  • major depressive disorder
  • preterm infants
  • bipolar disorder
  • low birth weight
  • preterm birth
  • pregnancy outcomes
  • sleep quality
  • emergency department