PET/MR imaging of inflammation in atherosclerosis.
Max L SendersClaudia CalcagnoAhmed TawakolMatthias NahrendorfWillem J M MulderZahi Adel FayadPublished in: Nature biomedical engineering (2022)
Myocardial infarction, stroke, mental disorders, neurodegenerative processes, autoimmune diseases, cancer and the human immunodeficiency virus impact the haematopoietic system, which through immunity and inflammation may aggravate pre-existing atherosclerosis. The interplay between the haematopoietic system and its modulation of atherosclerosis has been studied by imaging the cardiovascular system and the activation of haematopoietic organs via scanners integrating positron emission tomography and resonance imaging (PET/MRI). In this Perspective, we review the applicability of integrated whole-body PET/MRI for the study of immune-mediated phenomena associated with haematopoietic activity and cardiovascular disease, and discuss the translational opportunities and challenges of the technology.
Keyphrases
- positron emission tomography
- cardiovascular disease
- computed tomography
- human immunodeficiency virus
- contrast enhanced
- pet ct
- magnetic resonance imaging
- pet imaging
- oxidative stress
- high resolution
- hepatitis c virus
- antiretroviral therapy
- diffusion weighted imaging
- atrial fibrillation
- papillary thyroid
- magnetic resonance
- type diabetes
- cardiovascular events
- squamous cell carcinoma
- cardiovascular risk factors
- brain injury
- hiv positive
- fluorescence imaging
- mass spectrometry
- lymph node metastasis
- young adults
- quantum dots
- subarachnoid hemorrhage
- cerebral ischemia