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Serological study of CoronaVac vaccine and booster doses in Chile: immunogenicity and persistence of anti-SARS-CoV-2 spike antibodies.

Leonardo VargasNicolás ValdiviesoFabián TempioValeska SimonDaniela SaumaLucía ValenzuelaCaroll BeltránLoriana Castillo-DelgadoXimena Contreras-BenavidesMónica L AcevedoJohanna AcevedoRafael I GonzalezFernando Valiente-EcheverríaRicardo Soto-RifoMario RosemblattMercedes LopezFabiola OsorioMaría Rosa Bono
Published in: BMC medicine (2022)
Two doses of CoronaVac induces antibody titers against the SARS-CoV-2 ancestral strain which are lower in magnitude than those induced by the BNT162b2 vaccine. However, the response induced by CoronaVac can be greatly potentiated with a heterologous booster scheme with BNT162b2 or ChAdOx1 vaccines. Furthermore, the heterologous and homologous booster regimes induce a durable antibody response which does not show signs of decay 3 months after the booster dose.
Keyphrases
  • sars cov
  • respiratory syndrome coronavirus
  • dna damage
  • saccharomyces cerevisiae
  • coronavirus disease