Regulation of Monocyte Adhesion and Type I Interferon Signaling by CD52 in Patients With Systemic Sclerosis.

Michal RudnikFilip RolskiSuzana JordanTonja MerteljMara StellatoAnastasiia KozlovaPrzemysław BlyszczukGabriela Kania

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2021)

Down-regulation of the antiadhesion CD52 antigen in CD14+ monocytes represents a novel mechanism in the pathogenesis of SSc. Targeting of the IFN-HDAC-CD52 axis in monocytes might represent a new therapeutic option for patients with early SSc.

Keyphrases

systemic sclerosis
dendritic cells
interstitial lung disease
nk cells
peripheral blood
immune response
endothelial cells
escherichia coli
cystic fibrosis
pseudomonas aeruginosa
drug delivery
histone deacetylase
candida albicans