The STAT4 SLE risk allele rs7574865[T] is associated with increased IL-12-induced IFN-γ production in T cells from patients with SLE.
Niklas HagbergMartin JoelssonDag LeonardSarah ReidMaija-Leena ElorantaJohn MoMagnus K NilssonAnn-Christine SyvänenYenan T BrycesonLars RönnblomPublished in: Annals of the rheumatic diseases (2018)
T cells from patients with SLE carrying the STAT4 risk allele rs7574865[T] display an augmented response to IL-12 and IFN-α. This subset of patients may benefit from JAKi treatment.