Evaluation of TNF-α genetic polymorphisms as predictors for sepsis susceptibility and progression.

Anca Meda GeorgescuClaudia Violeta BănescuRazvan AzamfireiAdina HutanuValeriu MoldovanIudita BadeaSeptimiu VoidazanMinodora DobreanuIoana Raluca ChirtesLeonard Azamfirei

Published in: BMC infectious diseases (2020)

TNF-α +489G/A SNP A-allele carriage may confer protection against sepsis and septic shock development but apparently does not influence sepsis-related mortality. Promoter TNF-α SNPs did not affect transcription and were not associated with distinct sepsis, septic shock risk or outcomes.

Keyphrases

septic shock
rheumatoid arthritis
gene expression
type diabetes
cardiovascular events
intensive care unit
metabolic syndrome
weight loss
genetic diversity
drug induced