Influence of ABCC2, CYP2C8, and CYP2J2 Polymorphisms on Tacrolimus and Mycophenolate Sodium-Based Treatment in Brazilian Kidney Transplant Recipients.

Fabiana Dalla Vecchia GenvigirAlvaro M NishikawaClaudia R FelipeHelio Tedesco-SilvaNagilla OliveiraAntony B C SalazarJose O Medina-PestanaSonia Q DoiMario H HirataRosario D C Hirata

Published in: Pharmacotherapy (2017)

The ABCC2 c.3972C >T polymorphism affected tacrolimus C:D in Brazilian kidney transplant recipients. Further, CYP2C8*3 and CYP2J2 c.-76G>T SNPs influenced the renal function of these patients and the occurrence of adverse events during treatment with tacrolimus and mycophenolate sodium.

Keyphrases

end stage renal disease
ejection fraction
chronic kidney disease
prognostic factors
peritoneal dialysis
genome wide
replacement therapy