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XAF1 directs glioma response to temozolomide through apoptotic transition of autophagy by activation of ATM-AMPK signaling.

Min-Goo LeeZisun ChoiNa-Jung LimJi-Sun LimKyung-Woo LeeKyung-Phil KoByung-Kyu RyuShin-Hyuk KangSung-Gil Chi
Published in: Neuro-oncology advances (2022)
This study uncovers an important role for the XAF1-ATM-AMPK axis as a linchpin to govern glioma response to TMZ therapy.
Keyphrases
  • cell death
  • dna damage
  • dna repair
  • dna damage response
  • signaling pathway
  • protein kinase
  • endoplasmic reticulum stress
  • stem cells
  • newly diagnosed
  • replacement therapy