Molecular characterization of Chinese patients with small bowel adenocarcinoma.
Bryan JinBin LvZhengqing YanWenshuai LiHuan SongHaoshu CuiYao LiuBin ZhongXin ShenXiao LiBei ZhangShiqing ChenWanwei ZhengJie LiuFeifei LuoZhongguang LuoPublished in: Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico (2024)
The study found that in SBA tissues, the most commonly alternated genes were TP53, KRAS, and APC, and the most frequently affected pathways were RTK-RAS-MAPK, TP53, and WNT. Notably, the RTK-RAS-MAPK pathway was identified as a potential biomarker that could be targeted for treatment. Then, we validated the gene mutation profiling of ctDNA extracted from SBA patients exhibited the same characteristics as tissue samples for the first time. Subsequently, we applied ctDNA analysis on a terminal-stage patient who had shown no response to previous chemotherapy. After detecting alterations in the RTK-RAS-MAPK pathway in the ctDNA, the patient was treated with MEK + EGFR inhibitors and achieved a tumor shrinkage rate of 76.33%. Our study utilized the largest Chinese SBA cohort to uncover the molecular characteristics of this disease, which might facilitate clinical decision making for SBA patients.
Keyphrases
- end stage renal disease
- newly diagnosed
- signaling pathway
- ejection fraction
- chronic kidney disease
- oxidative stress
- peritoneal dialysis
- small cell lung cancer
- stem cells
- prognostic factors
- pi k akt
- small bowel
- gene expression
- wild type
- case report
- cell proliferation
- tyrosine kinase
- cancer therapy
- transcription factor
- circulating tumor cells