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Efficacy of Combined VEGFR1-3, PDGFα/β, and FGFR1-3 Blockade Using Nintedanib for Esophagogastric Cancer.

Elizabeth WonAzfar BasuniaWalid K ChatilaJaclyn F HechtmanJoanne F ChouGeoffrey Y KuSree B ChalasaniMichelle S BoyarZoe GoldbergAvni M DesaiYaelle TuvyMichael F BergerLaura TangDavid P KelsenMark SchattnerDavid H IlsonMarinela CapanuDavid B SolitNikolaus SchultzYelena Y Janjigian
Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)
Nintedanib treatment resulted in modest disease stabilization in patients with metastatic esophagogastric cancer. Alterations in cell-cycle pathway genes and increased global copy-number alteration (CNA) burden warrant further study as prognostic or predictive biomarkers.
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