Efficacy of Combined VEGFR1-3, PDGFα/β, and FGFR1-3 Blockade Using Nintedanib for Esophagogastric Cancer.
Elizabeth WonAzfar BasuniaWalid K ChatilaJaclyn F HechtmanJoanne F ChouGeoffrey Y KuSree B ChalasaniMichelle S BoyarZoe GoldbergAvni M DesaiYaelle TuvyMichael F BergerLaura TangDavid P KelsenMark SchattnerDavid H IlsonMarinela CapanuDavid B SolitNikolaus SchultzYelena Y JanjigianPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)
Nintedanib treatment resulted in modest disease stabilization in patients with metastatic esophagogastric cancer. Alterations in cell-cycle pathway genes and increased global copy-number alteration (CNA) burden warrant further study as prognostic or predictive biomarkers.
Keyphrases
- cell cycle
- copy number
- papillary thyroid
- mitochondrial dna
- genome wide
- idiopathic pulmonary fibrosis
- squamous cell
- cell proliferation
- interstitial lung disease
- dna methylation
- gene expression
- childhood cancer
- systemic sclerosis
- vascular endothelial growth factor
- vascular smooth muscle cells
- smoking cessation
- transcription factor